Slit Homolog 2 Protein

Preferred Label : Slit Homolog 2 Protein;

NCIt synonyms : Slit Homolog 2; Slit-2;

NCIt definition : Slit homolog 2 protein (1529 aa, 170 kDa) is encoded by the human SLIT2 gene. This protein is involved in the modulation of cell migration and the development of the nervous system.;

NCIt note : Slit homolog 2 protein is a ligand for both roundabout homolog 1 and 2; it also can bind to gremlin-1.; Slit homolog 2 protein is cleaved into an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot.. The Slit homolog 2 protein N-terminal product may repress olfactory bulb axon growth and induce dorsal root ganglia axon migration. (UniProt);

Details

Origin ID

C126787;

UMLS CUI

C1741674;

Automatic exact mappings (from CISMeF team)
- Slit guidance ligand 2 [OMIM gene]
- slit homolog 2 protein [MeSH Supplementary Concept]
- slit homolog 2 protein [MeSH concept]
OMIM relation
- Slit guidance ligand 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SLIT2 protein, human [MeSH concept]
- SLIT2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SLIT2 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Fetal Liver [NCIt concept]
- Fetal Lung [NCIt concept]
- Spinal Cord [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Leucine-Rich Repeat [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Chemotaxis Inhibition [NCIt concept]
- Nervous System Development [NCIt concept]
- Neural Development [NCIt concept]
- Receptor Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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