Thyroid Peroxidase

Preferred Label : Thyroid Peroxidase;

NCIt synonyms : Iodinase; Iodotyrosine Deiodase; Iodoperoxidase (Heme Type); Tyrosine Iodinase; EC 1.11.1.8; Iodotyrosine Deiodinase; Iodide Peroxidase; Monoiodotyrosine Deiodinase; TPO;

NCIt related terms : Thyroperoxidase;

NCIt definition : Thyroid peroxidase (933 aa, 103 kDa) is encoded by the human TPO gene. This protein plays a role in thyroid hormone synthesis.;

Alternative definition : CDISC: An antigen encoded by the TPO gene that regulates thyroid hormones synthesis. It can be considered as an autoantigen and is commonly associated with autoimmune thyroid disease.;

Details

Origin ID

C16752;

UMLS CUI

C1429427;

Currated CISMeF NLP mapping
- iodide peroxidase [MeSH Descriptor]
- iodide peroxidase [MeSH concept]
- iodide peroxidase [SNOMED Notion]
False automatic mappings
- Iodide peroxidase (substance) [SNOMED CT concept]
OMIM relation
- Thyroid peroxidase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- TPO protein, human [MeSH concept]
- TPO protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
- TPO Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_is_element_in_pathway
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Tyrosine Metabolism Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Graves Disease [NCIt concept]
- Hyperthyroidism [NCIt concept]
gene_product_plays_role_in_biological_process
- Biosynthetic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Methimazole [NCIt concept]

Keyword's position in hierarchy(ies) :

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