Hepatocyte Growth Factor Activator

Preferred Label : Hepatocyte Growth Factor Activator;

NCIt synonyms : EC 3.4.21.-; HGFA; HGF Activator; HGFAC;

NCIt definition : Hepatocyte growth factor activator (655 aa, 71 kDa) is encoded by the human HGFAC gene. This protein is involved in the proteolysis of single-chain hepatocyte growth factor.;

NCIt note : Hepatocyte growth factor activator is secreted as an inactive single-chain precursor and proteolyzed to generate the enzymatically active heterodimeric form comprised of a short chain and a long chain linked by a disulfide bond. (UniProt);

Details

Origin ID

C127008;

UMLS CUI

C5442156;

Automatic exact mappings (from CISMeF team)
- HGF activator [HGNC gene]
- Hepatocyte growth factor activator [OMIM gene]
Currated CISMeF NLP mapping
- HGF activator [MeSH Supplementary Concept]
- HGF activator [MeSH concept]
OMIM relation
- Hepatocyte growth factor activator [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HGF activator [MeSH Supplementary Concept]
- HGF activator [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HGFAC Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Hepatic Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Kringle Domain [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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