Sortilin-Related Receptor

Preferred Label : Sortilin-Related Receptor;

NCIt synonyms : SorLA-1; LDLR Relative With 11 Ligand-Binding Repeats; Sorting Protein-Related Receptor Containing LDLR Class A Repeats; Mosaic Protein LR11; Low-Density Lipoprotein Receptor Relative With 11 Ligand-Binding Repeats; LR11; SorLA;

NCIt definition : Sortilin-related receptor (2214 aa, 248 kDa) is encoded by the human SORL1 gene. This protein is involved in both endocytosis and protein trafficking.;

NCIt note : Sortilin-related receptor may be involved in transporting amyloid beta A4 protein (APP) to the Golgi. This may prevent APP trafficking to late endosomes where it would be proteolytically processed to form beta amyloid. (UniProt);

Details

Origin ID

C126511;

UMLS CUI

C1307867;

Automatic exact mappings (from CISMeF team)
- LR11 (body structure) [SNOMED CT concept]
- Sortilin-related receptor [OMIM gene]
- sortilin related receptor 1 [ORDO Gene]
- sortilin related receptor 1 [HGNC gene]
OMIM relation
- Sortilin-related receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- SORL1 protein, human [MeSH Supplementary Concept]
- SORL1 protein, human [MeSH concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- SORL1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Protein Turnover [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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