Pro-Neuregulin-1, Membrane-Bound Isoform

Preferred Label : Pro-Neuregulin-1, Membrane-Bound Isoform;

NCIt synonyms : Pro-NRG1; Pro-Neuregulin-1;

NCIt definition : Pro-neuregulin-1, membrane-bound isoform (640 aa, 70 kDa) is encoded by the human NRG1 gene. This protein plays a role in tyrosine kinase receptor-mediated signal transduction.;

NCIt note : The active form of the growth factor, neuregulin-1, is produced by two proteolytic cleavage events that remove the 19 N-terminal amino acid signal sequence and 399 amino acids from the C-terminus of pro-neuregulin-1, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C118414;

UMLS CUI

C3888287;

OMIM relation
- Neuregulin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- NRG1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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