Protein Delta Homolog 1

Preferred Label : Protein Delta Homolog 1;

NCIt synonyms : pG2; DLK-1;

NCIt definition : Protein delta homolog 1 (383 aa, 41 kDa) is encoded by the human DLK1 gene. This protein plays a role in intercellular communication.;

NCIt note : Protein delta homolog 1 can undergo proteolytically processing which removes the transmembrane and cytoplasmic domains and liberates an extracellular form called fetal antigen 1. (UniProt);

Details

Origin ID

C99662;

UMLS CUI

C3274856;

Automatic exact mappings (from CISMeF team)
- Delta-like noncanonical notch ligand 1 [OMIM gene]
- delta like non-canonical Notch ligand 1 [ORDO Gene]
OMIM relation
- Delta-like noncanonical notch ligand 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DLK1 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Ligand Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Extracellular Protein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
gene_product_is_element_in_pathway
- FOXA2 and FOXA3 Transcription Factor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-DLK-1 Antibody-drug Conjugate ADCT-701 [NCIt concept]
- Anti-DLK-1/MMAE Antibody-drug Conjugate TORL-4-500 [NCIt concept]
- DLK1/EPHA2/HBB/NRP1/RGS5/TEM1 Peptide-pulsed Alpha-type-1 Polarized Dendritic Cell Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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