Preferred Label : Anti-DLK-1/MMAE Antibody-drug Conjugate TORL-4-500;
NCIt synonyms : Antibody-drug Conjugate TORL-4-500; Anti-DLK-1 Antibody-drug Conjugate TORL-4-500; Anti-DLK-1 ADC TORL-4-500; ADC TORL-4-500; Anti-DLK-1/MMAE ADC TORL-4-500;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against human delta-like 1 homolog protein (DLK-1; DLK1) conjugated, via a cleavable
linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic
activity. Upon administration of anti-DLK-1/MMAE ADC TORL-4-500, the anti-DLK-1 antibody
moiety targets and binds to DLK-1 expressed on tumor cells. Upon binding, internalization,
and linker cleavage, MMAE binds to tubulin and inhibits its polymerization, which
results in G2/M phase arrest and induces apoptosis in DLK-1-expressing tumor cells.
DLK-1, an epidermal growth factor (EGF)-like membrane bound protein overexpressed
by certain tumor cell types and on certain cancer stem cells (CSCs), plays a key role
in tumor cell proliferation. Its expression is widely expressed during fetal development
but in adult healthy tissue it is very restricted.;
Molecule name : TORL 4-500; TORL4-500;
NCI Metathesaurus CUI : CL1922423;
Origin ID : C203533;
UMLS CUI : C5908009;
Semantic type(s)
- concept_is_in_subset
- has_target
