Preferred Label : Anti-DLK-1 Antibody-drug Conjugate ADCT-701;
NCIt synonyms : PBD Dimer-based ADC ADCT-701; ADC ADCT-701; Anti-DLK-1/PBD ADC ADCT-701;
NCIt definition : An antibody-drug conjugate (ADC) composed of HuBa-1-3D, a humanized immunoglobulin
G1 (IgG1) monoclonal antibody directed against human delta-like 1 homolog protein
(DLK-1; DLK1) and site-specifically conjugated to PL1601, which contains a valine-alanine
cleavable linker and SG3199, a cytotoxic pyrrolobenzodiazepine (PBD) dimer, with potential
antineoplastic activity. Upon administration of anti-DLK-1 ADC ADCT-701, the antibody
moiety targets and binds to DLK-1, which is expressed on the surfaces of a variety
of cancer cell types. Upon endocytosis and enzymatic cleavage by cathepsin, free PBD
is released and forms highly cytotoxic DNA interstrand cross-links, thereby blocking
cell division and killing DLK-1-expressing cancer cells. DLK-1, an epidermal growth
factor (EGF)-like membrane bound protein overexpressed by certain tumor cell types
and on certain cancer stem cells (CSCs), plays a key role in tumor cell proliferation.
Its expression is widely expressed during fetal development but in adult healthy tissue
it is very restricted.;
Molecule name : ADCT 701; ADCT-701;
Origin ID : C201679;
concept_is_in_subset
- has_target
