Probetacellulin

Preferred Label : Probetacellulin;

NCIt definition : Probetacellulin (178 aa, 20 kDa) is encoded by the human BTC gene. This protein plays a role in cellular proliferation.;

NCIt note : The active form of the growth factor, called betacellulin, is produced by proteolytic cleavage that removes 67 amino acids from the C-terminus of probetacellulin. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C118373;

UMLS CUI

C3897853;

OMIM relation
- Betacellulin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- BTC Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Environment-to-Cell Communication [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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