Proepiregulin - CISMeF

Preferred Label : Proepiregulin;

NCIt synonyms : EREG; Epiregulin;

NCIt definition : Proepiregulin (169 aa, 19 kDa) is encoded by the human EREG gene. This protein plays a role in the promotion of cell proliferation.;

NCIt note : The active form of the growth factor, epiregulin, is produced by two proteolytic cleavage events that remove 59 N-terminal amino acids and 61 amino acids from the C-terminus of proepiregulin. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C118410;

UMLS CUI

C3888282;

Automatic exact mappings (from CISMeF team)
- Epiregulin [MeSH concept]
- Epiregulin [MeSH Descriptor]
- Epiregulin [OMIM gene]
- epiregulin [HGNC gene]
OMIM relation
- Epiregulin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- EREG Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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