Epidermal Growth Factor-Like Protein 6

Preferred Label : Epidermal Growth Factor-Like Protein 6;

NCIt synonyms : EGFL6 Protein; EGF-Like Domain-Containing Protein 6; MAM Domain- and EGF Domain-Containing Protein; MAEG; Epidermal Growth Factor Repeat Containing Protein; MAM and EGF Domains-Containing Gene Protein; EGFL6; EGF Repeat-Containing Protein 6; EGF-Like 6; W80; MAM- and EGF-Containing Protein; Epidermal Growth Factor-Like Protein-6; EGF-Like Protein 6;

NCIt definition : Epidermal growth factor-like protein 6 (553 aa, 61 kDa) is encoded by the human EGFL6 gene. This protein plays a role in signaling and matrix remodeling.;

NCIt note : This glycoprotein contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an Arg-Gly-Asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. (From LocusLink, Swiss-Prot);

Details

Origin ID

C26154;

UMLS CUI

C0911758;

OMIM relation
- Epidermal growth factor-like 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- EGFL6 protein, human [MeSH concept]
- EGFL6 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- EGFL6 Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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