Prolow-Density Lipoprotein Receptor-Related Protein 1

Preferred Label : Prolow-Density Lipoprotein Receptor-Related Protein 1;

NCIt synonyms : CD91 Antigen; Apolipoprotein E Receptor; APOER; A2MR; CD Antigen CD91; Alpha-2-Macroglobulin Receptor; CD91; LRP-1; LRP1;

NCIt definition : Prolow-density lipoprotein receptor-related protein 1 (4544 aa, 505 kDa) is encoded by the human LRP1 gene. This protein is involved in the mediation of endocytosis and turnover.;

NCIt note : Prolow-density lipoprotein receptor-related protein 1 is processed by furin to two domains. One has an apparent molecular weight of 85 kDa and is a transmembrane protein and a the other has an apparent molecular weight of 515 kDa and is an extracellular domain that remains associated with the cell surface through non-covalent bonds to the 85 kDa portion. (UniProt);

Details

Origin ID

C95474;

UMLS CUI

C2987172;

OMIM relation
- Low density lipoprotein receptor-related protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- LRP1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- AlphaM/Beta2 Integrin Signaling Pathway [NCIt concept]
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Malaria Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein Turnover [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Paclitaxel Trevatide [NCIt concept]

Keyword's position in hierarchy(ies) :

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