CD97 Antigen - CISMeF

Preferred Label : CD97 Antigen;

NCIt synonyms : CD97; Adhesion G Protein-Coupled Receptor E5; Leukocyte Antigen CD97; ADGRE5; Adhesion G-Protein Coupled Receptor E5;

NCIt definition : CD97 antigen (835 aa, 92 kDa) is encoded by the human ADGRE5 gene. This protein plays a role in G protein-coupled receptor signaling, cell adhesion and leukocyte migration.;

NCIt note : CD97 Antigen, encoded by the CD97 gene, is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules. CD97 Antigen is a glycoprotein present on the surface of most activated leukocytes and is a G protein-coupled receptor. This protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing generates two variants. CD97 Antigen has large N-terminal domain with five epidermal growth factor-like sequences which are differentially spliced.;

Details

Origin ID

C25798;

UMLS CUI

C4721818;

OMIM relation
- Adhesion g protein-coupled receptor e5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- ADGRE5 protein, human [MeSH Supplementary Concept]
- Lymphocyte antigen CD97 (substance) [SNOMED CT concept]
- lymphocyte antigen cd97 [SNOMED Notion]
gene_encodes_gene_product
- ADGRE5 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- B-Lymphocyte [NCIt concept]
- Dendritic Cell [NCIt concept]
- Macrophage [NCIt concept]
- Smooth Muscle Cell [NCIt concept]
- T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_malfunction_associated_with_disease
- Digestive System Neuroendocrine Tumor G1 [NCIt concept]
- Thyroid Gland Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Motility [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immune Response Process [NCIt concept]
- Inflammatory Response [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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