Low-Density Lipoprotein Receptor

Preferred Label : Low-Density Lipoprotein Receptor;

NCIt synonyms : Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 3; LDLR; LDL Receptor; Low Density Lipoprotein Receptor;

NCIt definition : Low-density lipoprotein receptor (860 aa, 95 kDa) is encoded by the human LDLR gene. This protein is involved in the endocytosis of cholesterol.;

Details

Origin ID

C17074;

UMLS CUI

C3493221;

Currated CISMeF NLP mapping
- receptors, LDL [MeSH Descriptor]
- receptors, LDL [MeSH concept]
OMIM relation
- Low density lipoprotein receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- LDLR protein, human [MeSH concept]
- LDLR protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- LDLR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Endocytosis Pathway [NCIt concept]
- LDL Pathway [NCIt concept]
- Lipid Synthesis Pathway [NCIt concept]
- Regulation of Cholesterol Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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