Preferred Label : receptors, LDL;
MeSH definition : Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The
receptors are localized in specialized regions called coated pits. Hypercholesteremia
is caused by an allelic genetic defect of three types: 1, receptors do not bind to
LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization
of LDL. In consequence, entry of cholesterol esters into the cell is impaired and
the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase
is lacking.;
MeSH synonym : lipoprotein ldl receptors; receptors, lipoprotein ldl; low density lipoprotein receptor; ldl receptors; receptors, lipoprotein, ldl; ldl receptors, lipoprotein; low density lipoprotein receptors; receptors, low density lipoprotein; ldl receptor; receptor, ldl;
MeSH annotation : DF: RECEPT LDL;
Is substance : O;
Origin ID : D011973;
UMLS CUI : C0034821;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- AMG-220 [MeSH Supplementary Concept]
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The
receptors are localized in specialized regions called coated pits. Hypercholesteremia
is caused by an allelic genetic defect of three types: 1, receptors do not bind to
LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization
of LDL. In consequence, entry of cholesterol esters into the cell is impaired and
the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase
is lacking.
