Proheparin-Binding EGF-Like Growth Factor

Preferred Label : Proheparin-Binding EGF-Like Growth Factor;

NCIt synonyms : Pro-HB-EGF;

NCIt definition : Proheparin-binding EGF-like growth factor (208 aa, 23 kDa) is encoded by the human HBEGF gene. This protein plays a role in both heart valve formation and mitogenesis for fibroblasts and smooth muscle cells.;

NCIt note : The active form of the growth factor, called heparin-binding EGF-like growth factor, is produced by two proteolytic cleavage events that remove 62 N-terminal amino acids and 60 amino acids from the C-terminus of proheparin-binding EGF-like growth factor. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C118380;

UMLS CUI

C3888283;

OMIM relation
- Heparin-binding egf-like growth factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- HBEGF Gene [NCIt concept]
gene_product_expressed_in_tissue
- Fibroblast [NCIt concept]
- Smooth Muscle Cell [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Heparin Binding Growth Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Heparin Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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