Pro-Epidermal Growth Factor

Preferred Label : Pro-Epidermal Growth Factor;

NCIt synonyms : ProEGF;

NCIt definition : Pro-epidermal growth factor (1207 aa, 134 kDa) is encoded by the human EGF gene. This protein plays a role in the modulation of cell proliferation and differentiation.;

NCIt note : The active form of the growth factor, epidermal growth factor, is produced by two proteolytic cleavage events that remove 970 N-terminal amino acids and 184 amino acids from the C-terminus of pro-epidermal growth factor. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C118403;

UMLS CUI

C3897855;

Automatic exact mappings (from CISMeF team)
- epidermal growth factor [ORDO Gene]
- epidermal growth factor [HGNC gene]
- epidermal growth factor precursor [MeSH Supplementary Concept]
- pro-EGF [MeSH concept]
OMIM relation
- Epidermal growth factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EGF Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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