" /> Pro-Neuregulin-2, Membrane-Bound Isoform - CISMeF





Preferred Label : Pro-Neuregulin-2, Membrane-Bound Isoform;

NCIt synonyms : Pro-NRG2; Pro-Neuregulin-2;

NCIt definition : Pro-neuregulin-2, membrane-bound isoform (850 aa, 92 kDa) is encoded by the human NRG2 gene. This protein plays a role in receptor signaling.;

NCIt note : The active form of the growth factor, neuregulin-2, is produced by two proteolytic cleavage events that remove the 111 N-terminal amino acid propeptide and 446 amino acids from the C-terminus of pro-neuregulin-2, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

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29/07/2025


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