NCIt definition : Pro-neuregulin-2, membrane-bound isoform (850 aa, 92 kDa) is encoded by the human
NRG2 gene. This protein plays a role in receptor signaling.;
NCIt note : The active form of the growth factor, neuregulin-2, is produced by two proteolytic
cleavage events that remove the 111 N-terminal amino acid propeptide and 446 amino
acids from the C-terminus of pro-neuregulin-2, membrane-bound isoform. The precursor
is a type I membrane protein and the mature form is a secreted protein. (UniProt);