Lactadherin - CISMeF

Preferred Label : Lactadherin;

NCIt synonyms : Breast Epithelial Antigen BA46; MFGE8; Lactadherin Precursor; MFG-E8; Sperm Associated Antigen 10; Milk Fat Globule-EGF Factor 8; Sperm Surface Protein HP47; Secreted EGF Repeat and Discoidin Domains-Containing Protein 1; O-Acetyl Disialoganglioside Synthase; Milk Fat Globule-EGF Factor-8 Protein; SED1; MFGM; Milk Fat Globule-EGF Factor 8 Protein; HMFG;

NCIt definition : Lactadherin (387 aa, 43 kDa) is encoded by the human MFGE8 gene. This protein plays a role in cell adhesion, phagocytosis of apoptotic cells, integrin binding, intestinal epithelial homeostasis and the promotion of mucosal healing.;

NCIt note : Lactadherin is a multidomain cell surface (and secreted) protein that contains an EGF-like domain, C-terminal F5/8 type C domains, and the cell adhesion tripeptide RGD. It is expressed in mammary epithelia and by activated macrophages. MFGE8 recognizes aminophospholipids (phosphatidylserine) and binds to cells via its RGD motif; MFGE8 binds strongly to cells expressing alpha-V/beta-3 integrin.; Lactadherin is cleaved at amino acid positions 265 and 317, which releases a 50 amino acid peptide called medin. Medin is the predominant protein in aortic medial amyloid.;

Details

Origin ID

C26388;

UMLS CUI

C0388561;

OMIM relation
- Milk fat globule-egf factor 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MFGE8 protein, human [MeSH concept]
- MFGE8 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- MFGE8 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epithelial Cell [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- RGD Motif [NCIt concept]
gene_product_is_element_in_pathway
- Integrin Angiogenesis Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Breast Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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