Geldanamycin Analogue

Preferred Label : Geldanamycin Analogue;

NCIt related terms : geldanamycin analog;

NCIt definition : An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.;

Alternative definition : NCI-GLOSS: An antineoplastic antibiotic drug that belongs to the family of drugs called ansamycins.;

NSC code : 255107; 255104; 210757;

Codes from synonyms : CDR0000046204;

Details

Origin ID

C2516;

UMLS CUI

C0796552;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Heat Shock Protein 90 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Chaperone Protein Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Protein Degradation Induction [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Geldanamycin Analogue/Gemcitabine [NCIt concept]
- Docetaxel/Geldanamycin Analogue [NCIt concept]

Keyword's position in hierarchy(ies) :

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