Retaspimycin Hydrochloride

Preferred Label : Retaspimycin Hydrochloride;

NCIt synonyms : 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride; Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-, monohydrochloride;

NCIt definition : The hydrochloride salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of HSP90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis.;

UNII : 928Q33Q049;

InChIKey : OIRUWDYJGMHDHJ-AFXVCOSJSA-N;

CAS number : 857402-63-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 857402-63-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : IPI-504;

Chemical formula : C31H45N3O8.HCl;

Details

Origin ID

C48401;

UMLS CUI

C2700600;

Automatic exact mappings (from CISMeF team)
- tanespimycin [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- retaspimycin hydrochloride [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- retaspimycin hydrochloride [MeSH concept]
chemical_or_drug_affects_gene_product
- Heat Shock Protein 90 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Chaperone Protein Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Protein Degradation Induction [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Retaspimycin [NCIt concept]
has_target
- Heat Shock Protein 90 [NCIt concept]
is_salt_form_of
- Retaspimycin [NCIt concept]

Keyword's position in hierarchy(ies) :

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