Retaspimycin - CISMeF

Preferred Label : Retaspimycin;

NCIt synonyms : Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-; 17-Allylamino-17-demethoxygeldanamycin Hydroquinone;

NCIt definition : A small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of HSP90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis.;

UNII : BZF2ZM0I5Z;

InChIKey : OAKGNIRUXAZDQF-TXHRRWQRSA-N;

CAS number : 857402-23-4;

Chemical formula : C31H45N3O8;

Codes from synonyms : 439;

Détails

Origin ID

C80378;

UMLS CUI

C1743502;

Automatic exact mappings (from CISMeF team)
- tanespimycin [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- 17-allylamino-17-demethoxygeldanamycin hydroquinone [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 17-allylamino-17-demethoxygeldanamycin hydroquinone [MeSH concept]
chemical_or_drug_affects_gene_product
- Heat Shock Protein 90 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Chaperone Protein Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Protein Degradation Induction [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Retaspimycin Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Retaspimycin Hydrochloride [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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