Alvespimycin Hydrochloride

Preferred Label : Alvespimycin Hydrochloride;

NCIt synonyms : Geldanamycin,17-demethoxy-17-((2-(dimethylamino)ethyl)amino)-, Monohydrochloride; 17-DMAG HCl;

NCIt definition : The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.;

UNII : 612K359T69;

InChIKey : DFSYBWLNYPEFJK-IHLRWNDRSA-N;

CAS number : 467214-21-7;

Molecule name : KOS-1022; BMS-826476;

Chemical formula : C32H48N4O8.ClH;

Details

Origin ID

C76665;

UMLS CUI

C2698077;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Heat Shock Protein 90 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Chaperone Protein Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Protein Degradation Induction [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Alvespimycin [NCIt concept]
has_target
- Heat Shock Protein 90 [NCIt concept]
is_salt_form_of
- Alvespimycin [NCIt concept]

Keyword's position in hierarchy(ies) :

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