NCIt definition : The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone
antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids
in the assembly, maturation and folding of proteins. Subsequently, the function of
Hsp90 is inhibited, leading to the degradation and depletion of its client proteins
such as kinases and transcription factors involved with cell cycle regulation and
signal transduction.;
UNII : 612K359T69;
InChIKey : DFSYBWLNYPEFJK-IHLRWNDRSA-N;
CAS number : 467214-21-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 467214-21-7
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