Preferred Label : Saracatinib Difumarate;
NCIt synonyms : 4-Quinazolinamine, N-(5-Chloro-1,3-Benzodioxol-4-yl)-7-(2-(4-Methyl-1-Piperazinyl)Ethoxy)-5-((Tetrahydro-2H-Pyran-4-yl)Oxy)-,
(2e)-2-Butenedioate (1:2); N-(5-Chloro-1,3-Benzodioxol-4-yl)-7-(2-(4-Methylpiperazin-1-yl)Ethoxy)-5-(Tetrahydro-2H-Pyran-4-yloxy)Quinazolin-4-Amine
Di((2e)-but-2-Enedioate);
NCIt definition : The difumarate salt of saracatinib, an orally available 5-, 7-substituted anilinoquinazoline
with anti-invasive and anti-tumor activities. Saracatinib is a dual-specific inhibitor
of Src and Abl, protein tyrosine kinases that are overexpressed in chronic myeloid
leukemia cells. This agent binds to and inhibits these tyrosine kinases and affects
cell motility, cell migration, adhesion, invasion, proliferation, differentiation,
and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone
resorption.;
UNII : 8R1DYT4EAW;
InChIKey : OQXMMAQEMJUIQM-LVEZLNDCSA-N;
CAS number : 893428-72-3;
Molecule name : AZD-0530 Difumarate;
Chemical formula : C27H32ClN5O5.2C4H4O4;
Origin ID : C95224;
UMLS CUI : C2987006;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
