" /> Lifirafenib - CISMeF





Preferred Label : Lifirafenib;

NCIt synonyms : Begeine-283;

NCIt definition : An inhibitor of the serine/threonine protein kinase B-raf (BRAF) and epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Lifirafenib selectively binds to and inhibits the activity of BRAF and certain BRAF mutant forms, and EGFR. This prevents BRAF- and EGFR-mediated signaling and inhibits the proliferation of tumor cells that either contain a mutated BRAF gene or express over-activated EGFR. In addition, BGB-283 inhibits mutant forms of the Ras proteins K-RAS and N-RAS. BRAF and EGFR are mutated or upregulated in many tumor cell types.;

UNII : 8762XZS5ZF;

InChIKey : NGFFVZQXSRKHBM-FKBYEOEOSA-N;

CAS number : 1446090-79-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1446090-79-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BGB 283; BGB-283;

NCI Metathesaurus CUI : CL503841;

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Keyword's position in hierarchy(ies) : arborescence

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14/05/2024


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