NCIt definition : The maleate salt form of lifirafenib, an inhibitor of the serine/threonine protein
kinase B-raf (BRAF) and epidermal growth factor receptor (EGFR), with potential antineoplastic
activity. Lifirafenib selectively binds to and inhibits the activity of BRAF and certain
BRAF mutant forms, and EGFR. This prevents BRAF- and EGFR-mediated signaling and inhibits
the proliferation of tumor cells that either contain a mutated BRAF gene or express
over-activated EGFR. In addition, lifirafenib inhibits mutant forms of the Ras proteins
K-RAS and N-RAS. BRAF and EGFR are mutated or upregulated in many tumor cell types.;
Semantic type(s)