Menin - CISMeF

Preferred Label : Menin;

NCIt synonyms : MEN1;

NCIt definition : Menin (615 aa, 68 kDa) is encoded by the human MEN1 gene. This protein is involved in the negative regulation of transcription, cell proliferation and signaling.;

NCIt note : Menin regulates transcription through direct inhibition of the JUND transcription factor, interacts with SMAD3 and appears to be required for SMAD3/4-DNA binding at transcriptional regulatory sites. (from OMIM;

Détails

Origin ID

C18051;

UMLS CUI

C1321894;

OMIM relation
- Multiple endocrine neoplasia, type I [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Pediatric Oncology Target Genes/Proteins Terminology [NCIt concept]
gene_encodes_gene_product
- MEN1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_malfunction_associated_with_disease
- Multiple Endocrine Neoplasia Type 1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction Inhibition [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]
- Tumor Suppression [NCIt concept]
is_target
- Bleximenib [NCIt concept]
- Emilumenib [NCIt concept]
- Emilumenib Succinate [NCIt concept]
- Enzomenib [NCIt concept]
- Icovamenib [NCIt concept]
- Revumenib [NCIt concept]
- Ziftomenib [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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