Herbimycin - CISMeF

Preferred Label : Herbimycin;

NCIt synonyms : 17-Demethoxy-15-methoxy-11-O-methylgeldanamycin, (15R)-;

NCIt related terms : Herbimycin A;

NCIt definition : A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Herbimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04);

UNII : 815WDV2HST;

CAS number : 70563-58-5;

NSC code : 305978;

Codes from synonyms : 30532;

Details

Origin ID

C1124;

UMLS CUI

C0062565;

Currated CISMeF NLP mapping
- herbimycin [MeSH concept]
- herbimycin [MeSH Supplementary Concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- herbimycin [MeSH concept]
- herbimycin [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Heat Shock Protein 90 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Chaperone Protein Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Protein Degradation Induction [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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