" /> Radotinib - CISMeF





Preferred Label : Radotinib;

NCIt synonyms : 4-Methyl-N-(3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl)-3-(4-(pyrazin-2-yl)pyrimidin-2-ylamino)benzamide;

NCIt definition : A second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.;

UNII : I284LJY110;

InChIKey : DUPWHXBITIZIKZ-UHFFFAOYSA-N;

CAS number : 926037-48-1;

Molecule name : IY5511;

Chemical formula : C27H21F3N8O;

Codes from synonyms : 429;

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31/05/2025


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