Preferred Label : Henatinib Maleate;
NCIt synonyms : (R,Z)-2-[(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene) methyl]-5-(2-hydroxy-3-morpholinopropyl)-3-methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]
azepin-4-ketone Maleate;
NCIt definition : The maleate salt form of henatinib, an orally bioavalable, multitargeted tyrosine
kinase inhibitor with potential antitumor and antiangiogenic activities. Henatinib
inhibits vascular endothelial growth factor receptor type 2 (VEGFR2), a tyrosine kinase
receptor upregulated in many tumor cells that plays a key role in angiogenesis. This
may result in an inhibition of angiogenesis and eventually tumor cell proliferation.
Henatinib, structurally similar to sunitinib, also inhibits, though to a lesser extent,
mast/stem cell growth factor receptor (c-Kit) and, platelet-derived growth factor
receptor (PDGFR) alpha and beta.;
Origin ID : C97949;
UMLS CUI : C2935073;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
