Preferred Label : Henatinib;
NCIt synonyms : Pyrrolo(3,2-c)azepin-4(1H)-one, 2-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-5,6,7,8-tetrahydro-5-((2R)-2-hydroxy-3-(4-morpholinyl)propyl)-3-methyl-;
NCIt definition : An orally bioavailable, multitargeted tyrosine kinase inhibitor with potential antitumor
and antiangiogenic activities. Upon administration, henatinib inhibits vascular endothelial
growth factor receptor type 2 (VEGFR2), a tyrosine kinase receptor upregulated in
many tumor cells that plays a key role in angiogenesis. This may result in an inhibition
of angiogenesis and eventually tumor cell proliferation. Henatinib, structurally similar
to sunitinib, also inhibits, though to a lesser extent, mast/stem cell growth factor
receptor (c-Kit) and, platelet-derived growth factor receptor (PDGFR) alpha and beta.;
UNII : TE20GB753F;
CAS number : 1239269-51-2;
Origin ID : C213706;
chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
