" /> Gefitinib - CISMeF





Preferred Label : Gefitinib;

NCIt synonyms : N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholin) propoxy]-4-quinazolinamine; 4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline;

NCIt related terms : ZD 1839; Iressa;

NCIt definition : An anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. (NCI04);

Alternative definition : NCI-GLOSS: A drug that is used to treat certain types of non-small cell lung cancer and is being studied in the treatment of other types of cancer. It is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.;

UNII : S65743JHBS;

InChIKey : XGALLCVXEZPNRQ-UHFFFAOYSA-N;

CAS number : 184475-35-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 184475-35-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Iressa;

Molecule name : ZD 1839; ZD1839;

Chemical formula : C22H24ClFN4O3;

NSC code : 715055;

ChEBI ID : CHEBI:49668;

Codes from synonyms : NSC0715055; 31763; CDR0000258356; CDR0000508688; CDR0000046761; 242;

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11/05/2024


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