" /> Crenolanib - CISMeF





Preferred Label : Crenolanib;

NCIt synonyms : PDGFR Inhibitor CP-868596; 4-Piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1Hbenzimidazol-1-yl]-8-quinolinyl]-; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine; CP-868 596;

NCIt definition : An orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types.;

UNII : LQF7I567TQ;

InChIKey : DYNHJHQFHQTFTP-UHFFFAOYSA-N;

CAS number : 670220-88-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 670220-88-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : CP-868,596; CP-868596;

Chemical formula : C26H29N5O2;

Codes from synonyms : 117;

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Keyword's position in hierarchy(ies) : arborescence

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12/05/2024


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