NCIt definition : The besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting
the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related
tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration,
crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3,
which may result in the inhibition of PDGFR- and Flt3-related signal transduction
pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation
in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor
tyrosine kinases, are upregulated or mutated in many tumor cell types.;