BMP and Activin Membrane-Bound Inhibitor Homolog

Preferred Label : BMP and Activin Membrane-Bound Inhibitor Homolog;

NCIt synonyms : BAMBI; BMP and Activin Membrane-Bound Inhibitor; NMA; Putative Transmembrane Protein NMA; Putative Transmembrane Protein-NMA; Non-Metastatic Gene A Protein;

NCIt definition : BMP and activin membrane-bound inhibitor homolog (260 aa, 29 kDa) is encoded by the human BAMBI gene. This protein is involved in the inhibition of transforming growth factor-beta family-dependent signaling.;

NCIt note : BMP and activin membrane-bound inhibitor homolog (BAMBI) acts as a pseudoreceptor for transforming growth factor-beta (TGF-beta) family cytokines. The extracellular domain of BAMBI shares significant homology with TGF-beta receptors but lacks the intracellular serine/threonine kinase domain required for signaling. (EntrezGene);

Details

Origin ID

C33973;

UMLS CUI

C1436698;

OMIM relation
- Bmp and activin membrane-bound inhibitor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BAMBI protein, human [MeSH Supplementary Concept]
- BAMBI protein, human [MeSH concept]
gene_encodes_gene_product
- BAMBI Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Dominant Negative Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]

Keyword's position in hierarchy(ies) :

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