Dominant Negative Receptor

Preferred Label : Dominant Negative Receptor;

NCIt synonyms : Dominant-Negative Receptor;

NCIt definition : A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative receptor usually has an intact ligand binding region but is missing an intracellular enzymatic region. It may be a mutated form of a full length receptor or it may be in the same receptor family.;

Details

Origin ID

C19360;

UMLS CUI

C1333312;

Biochemical function of gene products
- BMP and Activin Membrane-Bound Inhibitor Homolog [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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