NCIt definition : Human FSTL3 wild-type allele is located within 19p13 and is approximately 7 kb in
length. This allele, which encodes follistatin-related protein 3, plays a role in
transcription, cell signaling and leukemogenesis.;
NCIt note : In addition to the t(11;19) translocation in a case of B-cell chronic lymphocytic
leukemia from which FSTL3 was isolated, rearrangement of the FSTL3 gene was also observed
in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma,
suggesting that FSTL3 may be involved in the leukemogenesis process.;