" /> ACHE wt Allele - CISMeF





Preferred Label : ACHE wt Allele;

NCIt synonyms : Acetylcholinesterase (YT Blood Group) Gene; Acetylcholinesterase (Cartwright Blood Group) wt Allele; N-ACHE; ACEE; ARACHE; Apoptosis-Related Acetylcholinesterase Gene; YT; Yt Blood Group Gene; Acetylcholinesterase Gene;

NCIt definition : Human ACHE wild-type allele is located in the vicinity of 7q22.1 and is approximately 7 kb in length. This allele, which encodes acetylcholinesterase protein, is involved in neuronal apoptosis, Cartwright (Yt) blood group antigen composition and acetylcholine catabolism.;

NCIt note : The ACHE gene is transcribed into at least 4 transcripts generated by 3-prime alternative splicing. All transcripts contain exons 1 through 4. Three of the transcripts are well characterized: tailed ACHE (ACHE-T; synaptic ACHE; ACHE-S), which includes exon 6 and is most frequently expressed in brain and muscle cells, hydrophobic ACHE (ACHE-H; erythrocytic ACHE; ACHE-E), which includes exon 5 and is expressed in erythrocytes, and readthrough ACHE (read-through ACHE; ACHE-R) includes intron 4 and exon 5.;

GenBank Accession Number : NM_015831;

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12/05/2024


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