Preferred Label : Edicotinib;
NCIt synonyms : 4-Cyano-1H-imidazole-2-carboxylic acid N-(2-(4,4-dimethylcyclohex-1-enyl)-6-(2,2,6,6-tetramethyltetrahydropyran-4-yl)pyridin-3-yl)amide; 4-Cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyl-tetrahydro-2H-pyran-4-yl)pyridin-3-yl)-1H-imidazole-2-carboxamide; 1H-Imidazole-2-carboxamide, 5-Cyano-N-(2-(4,4-dimethyl-1-cyclohexen-1-yl)-6-(tetrahydro-2,2,6,6-tetramethyl-2H-pyran-4-yl)-3-pyridinyl)-;
NCIt definition : A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor
(CSF1R; FMS) with potential antineoplastic activity. Edicotinib blocks the receptor-ligand
interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation
of FMS. As a result, unphosphorylated FMS can not activate FMS-mediated signaling
pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor
cells. FMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types
and plays an essential role in macrophage differentiation, recruitment, and activation
as well as the regulation of cell proliferation.;
UNII : 3NU609VYNF;
InChIKey : BNVPFDRNGHMRJS-UHFFFAOYSA-N;
CAS number : 1142363-52-7;
Molecule name : JNJ-40346527;
Origin ID : C101519;
UMLS CUI : C4079767;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
