NCIt definition : The hydrochloride salt form of edicotinib, a small molecule and orally available inhibitor
of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic
activity. Edicotinib blocks the receptor-ligand interaction between FMS and its ligand
CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated
FMS can not activate FMS-mediated signaling pathways, thus potentially inhibiting
cell proliferation in FMS-overexpressed tumor cells. FMS, a tyrosine kinase receptor,
is overexpressed in certain tumor cell types and plays an essential role in macrophage
differentiation, recruitment, and activation as well as the regulation of cell proliferation.;
Semantic type(s)