Pegdinetanib - CISMeF

Preferred Label : Pegdinetanib;

NCIt related terms : Angiocept; CT-322; VEGFR-2 inhibitor CT-322;

NCIt definition : A pegylated form of a thermostable and protease resistant peptide targeting human vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic activity. Derived from the 10th type III domain of human fibronectin and one of the natural ligands, pegdinetanib binds to VEGFR-2 and prevents activation of VEGFR-2 by other activating ligands. This may inhibit the growth of new tumor blood vessels.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. CT-322 may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor and a type of antiangiogenesis agent.;

UNII : SSB56T0M0L;

CAS number : 906450-24-6;

Drug name : Angiocept;

Molecule name : BMS-844203; CT-322;

Codes from synonyms : CDR0000600470; CDR0000600471; CDR0000600472;

Details

Origin ID

C62791;

UMLS CUI

C2987574;

See also inter- (CISMeF)
- CT-322 [MeSH Supplementary Concept]
- angiocept [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Receptor Tyrosine Kinase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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