Brivanib - CISMeF

Preferred Label : Brivanib;

NCIt synonyms : VEGFR2 Inhibitor BMS-540215; (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol;

NCIt definition : A pyrrolotriazine-based compound and an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antineoplastic activity. BMS-540215 specifically targets and binds strongly to human VEGFR-2, a tyrosine kinase receptor and pro-angiogenic growth factor expressed almost exclusively on vascular endothelial cells. Blockade of VEGFR-2 by this agent may lead to an inhibition of VEGF-stimulated endothelial cell migration and proliferation, thereby inhibiting tumor angiogenesis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. Brivanib may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor 2 inhibitor and a type of antiangiogenesis agent.;

UNII : DDU33B674I;

InChIKey : WCWUXEGQKLTGDX-LLVKDONJSA-N;

CAS number : 649735-46-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 649735-46-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BMS-540215;

Chemical formula : C19H19FN4O3;

Codes from synonyms : CDR0000601196;

Details

Origin ID

C67040;

UMLS CUI

C2700604;

Currated CISMeF NLP mapping
- brivanib [MeSH concept]
- brivanib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- brivanib [MeSH Supplementary Concept]
- brivanib [MeSH concept]
chemical_or_drug_affects_gene_product
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Receptor Tyrosine Kinase Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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