" /> Brivanib - CISMeF





Preferred Label : Brivanib;

NCIt synonyms : VEGFR2 Inhibitor BMS-540215; (R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol;

NCIt definition : A pyrrolotriazine-based compound and an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antineoplastic activity. BMS-540215 specifically targets and binds strongly to human VEGFR-2, a tyrosine kinase receptor and pro-angiogenic growth factor expressed almost exclusively on vascular endothelial cells. Blockade of VEGFR-2 by this agent may lead to an inhibition of VEGF-stimulated endothelial cell migration and proliferation, thereby inhibiting tumor angiogenesis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. Brivanib may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor 2 inhibitor and a type of antiangiogenesis agent.;

UNII : DDU33B674I;

InChIKey : WCWUXEGQKLTGDX-LLVKDONJSA-N;

CAS number : 649735-46-6;

Molecule name : BMS-540215;

Chemical formula : C19H19FN4O3;

Codes from synonyms : CDR0000601196;

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08/05/2025


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