Preferred Label : Carboxyamidotriazole;
NCIt synonyms : Carboxyaminoimidazole; Carboxyamido-triazole; 1H-1,2,3-Triazole-4-carboxamide, 5-amino-1-((3,5-dichloro-4(4-chlorobenzoyl)phenyl)methyl); 5-Amino-1-((3,5-dichloro-4-(4-chlorobenzoyl)phenyl)methyl)-1H-1,2,3-triazole-4-carboxamide; CAI;
NCIt definition : An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole
binds to and inhibits non-voltage-operated Ca2 channels, blocking both Ca2 influx
into cells and Ca2 release from intracellular stores and resulting in the disruption
of calcium channel-mediated signal transduction and inhibition of vascular endothelial
growth factor (VEGF) signaling, endothelial proliferation, and angiogenesis. This
agent may also inhibit tumor cell growth, invasion and metastasis. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called angiogenesis
inhibitors.;
UNII : 6ST3ZF52WB;
CAS number : 99519-84-3;
Molecule name : L651582;
NSC code : 609974;
Codes from synonyms : CDR0000045379; 20120;
Origin ID : C1141;
UMLS CUI : C0064494;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
