NCIt definition : The orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small
molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole
binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2 influx
into cells and Ca2 release from intracellular stores, resulting in the disruption
of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular
endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation,
tumor cell growth, invasion and metastasis.;
Semantic type(s)