Halofuginone - CISMeF

Preferred Label : Halofuginone;

NCIt synonyms : trans-( /-)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone;

NCIt definition : An orally-active quinazolinone alkaloid with potential antineoplastic activity. Halofuginone interferes with the signaling pathway of transforming growth factor beta (TGF beta) and inhibits expression of matrix metalloproteinase 2, thereby inhibiting collagen type I synthesis and inducing extracellular matrix degradation, resulting in inhibition of angiogenesis, tumor growth, or metastasis.;

UNII : L31MM1385E;

InChIKey : LVASCWIMLIKXLA-CABCVRRESA-N;

CAS number : 55837-20-2;

Chemical formula : C16H17BrClN3O3;

Codes from synonyms : NSC0713205;

Details

Origin ID

C1120;

UMLS CUI

C0062095;

Automatic exact mappings (from CISMeF team)
- 4(3h)-quinazolinone, 7-bromo-6-chloro-3-[3-[(2r,3s)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, rel- [Substance BNPC]
Currated CISMeF NLP mapping
- 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]quinazolin-4(3h)-one monohydrobromide [Substance BNPC]
- halofuginone [MeSH concept]
- halofuginone [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]quinazolin-4(3h)-one monohydrobromide [Substance BNPC]
- halofuginone [MeSH concept]
- halofuginone [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Transcriptional Repression [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Metastasis Suppression [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Halofuginone Hydrobromide [NCIt concept]
has_target
- 72 kDa Type IV Collagenase [NCIt concept]
- Transforming Growth Factor-Beta Superfamily [NCIt concept]
is_free_acid_or_base_form_of
- Halofuginone Hydrobromide [NCIt concept]

Keyword's position in hierarchy(ies) :

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