" /> Halofuginone Hydrobromide - CISMeF





Preferred Label : Halofuginone Hydrobromide;

NCIt synonyms : Halofuginone IV (intravenous);

NCIt definition : The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.;

Alternative definition : NCI-GLOSS: A substance that is being studied for its ability to slow the growth of connective tissue and to prevent the growth of new blood vessels that tumors need to grow. It is a type of quinazolinone alkaloid and a type of antiangiogenesis agent.;

UNII : PTC2969MV1;

InChIKey : SJUWEPZBTXEUMU-LIOBNPLQSA-N;

CAS number : 17395-31-2; 64924-67-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 17395-31-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 64924-67-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Tempostatin;

Molecule name : RU 19110;

Chemical formula : C16H17BrClN3O3.BrH;

NSC code : 713205;

Codes from synonyms : CDR0000045060; NSC0713205; 09501;

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14/05/2024


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