NCIt definition : The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial
derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic
activities. Halofuginone specifically inhibits collagen type I gene expression and
matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression
of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects
appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2
promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.;
Alternative definition : NCI-GLOSS: A substance that is being studied for its ability to slow the growth of
connective tissue and to prevent the growth of new blood vessels that tumors need
to grow. It is a type of quinazolinone alkaloid and a type of antiangiogenesis agent.;
UNII : PTC2969MV1;
InChIKey : SJUWEPZBTXEUMU-LIOBNPLQSA-N;
CAS number : 17395-31-2; 64924-67-0;
Drug name : Tempostatin;
Molecule name : RU 19110;
Chemical formula : C16H17BrClN3O3.BrH;
NSC code : 713205;
Codes from synonyms : CDR0000045060; NSC0713205; 09501;