Preferred Label : CSF1R Inhibitor PLX73086;
NCIt definition : An inhibitor of colony stimulating factor 1 receptor (CSF1R; CSF-1R), with potential
antineoplastic activity. Upon administration, CSF1R inhibitor PLX73086 targets and
binds to CSF1R, thereby blocking CSF1R activation and CSF1R-mediated signaling. This
inhibits the activity of tumor-associated macrophages (TAMs) in the tumor tissue and
prevents TAM-related tumor cell growth. CSF1R, also known as macrophage colony-stimulating
factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface
receptor for its ligand colony stimulating factor 1 (CSF1) and plays major roles in
tumor cell proliferation and metastasis.;
Molecule name : PLX7 3086; AC-708; PLX73086;
NCI Metathesaurus CUI : CL507868;
Origin ID : C129688;
UMLS CUI : C4329605;
Semantic type(s)
- concept_is_in_subset
- has_target
