Preferred Label : Sotuletinib;
NCIt synonyms : 4-((2-(((1R,2R)-2-hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide; 4-[2((1R,2R)-2-Hydroxycyclohexylamino)-benzothiazol-6-yloxyl]-pyridine- 2-carboxylic
Acid Methylamide; CSF-1R Inhibitor BLZ945;
NCIt definition : An orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF-1R;
CSF1R), with potential antineoplastic activity. CSF1R inhibitor BLZ945 selectively
binds to CSF1R expressed on tumor-associated macrophages (TAMs), blocks the activity
of CSF1R, and inhibits CSF1R-mediated signal transduction pathways. This inhibits
the activity and proliferation of TAMs, and reprograms the immunosuppressive nature
of existing TAMs. Altogether, this reduces TAM-mediated immune suppression in the
tumor microenvironment, re-activates the immune system, and improves anti-tumor cell
responses mediated by T-cells. CSF1R, also known as macrophage colony-stimulating
factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface
receptor for its ligand, colony stimulating factor 1 (CSF1); this receptor is overexpressed
by TAMs in the tumor microenvironment, and plays a major role in both immune suppression
and the induction of tumor cell proliferation.;
UNII : 7W3V82OQ0P;
CAS number : 953769-46-5;
Molecule name : BLZ 945; BLZ-945;
Origin ID : C129653;
UMLS CUI : C5667156;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
