NCIt definition : An orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF1R; CSF-1R;
CD115; M-CSFR), with potential immunomodulatory and antineoplastic activities. Upon
oral administration, pimicotinib targets and binds to CSF1R, thereby blocking CSF1R
activation and CSF1R-mediated signaling. This inhibits the activities of tumor-associated
macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), and prevents immune
suppression in the tumor microenvironment (TME). This enhances antitumor T-cell immune
responses and inhibits the proliferation of tumor cells. CSF1R, also known as macrophage
colony-stimulating factor receptor (M-CSFR) and CD115 (cluster of differentiation
115), is a cell-surface receptor that plays major roles in tumor cell proliferation
and metastasis.;