Preferred Label : cFMS Tyrosine Kinase Inhibitor ARRY-382;
NCIt definition : A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor
(CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor
ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating
factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in
cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed
in certain tumor cell types and plays an essential role in macrophage differentiation
and regulation of cell proliferation.;
Molecule name : ARRY-382;
NCI Metathesaurus CUI : CL429011;
Origin ID : C96227;
UMLS CUI : C3272658;
Semantic type(s)
- concept_is_in_subset
- has_target
